Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification

Antibodies can rapidly evolve in specific response to antigens. Affinity maturation drives this evolution through cycles of mutation and selection leading to enhanced antibody specificity and affinity. Elucidating the biophysical mechanisms that underlie affinity maturation is fundamental to underst...

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Библиографические подробности
Опубликовано в: :Front Immunol
Главные авторы: Jeliazkov, Jeliazko R., Sljoka, Adnan, Kuroda, Daisuke, Tsuchimura, Nobuyuki, Katoh, Naoki, Tsumoto, Kouhei, Gray, Jeffrey J.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2018
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840193/
https://ncbi.nlm.nih.gov/pubmed/29545810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00413
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