Conversion of a murine monoclonal antibody A13 targeting epidermal growth factor receptor to a human monoclonal antibody by guided selection

Epidermal growth factor receptor (EGFR) is an attractive target for tumor therapy because it is overexpressed in the majority of solid tumors and the increase in receptor expression levels has been linked with a poor clinical prognosis. Also it is well established that blocking the interaction of EG...

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Bibliografiska uppgifter
Huvudupphovsmän: Chang, Ki-Hwan, Kim, Min-Soo, Hong, Gwang-Won, Shin, Yong-Nam, Kim, Se-Ho
Materialtyp: Artigo
Språk:Inglês
Publicerad: Korean Society for Biochemistry and Molecular Biology 2012
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Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277898/
https://ncbi.nlm.nih.gov/pubmed/22064379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2012.44.1.005
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