Characterization of a novel anti-human TNF-α murine monoclonal antibody with high binding affinity and neutralizing activity

In order to develop an anti-human TNF-α mAb, mice were immunized with recombinant human TNF-α. A murine mAb, TSK114, which showed the highest binding activity for human TNF-α was selected and characterized. TSK114 specifically bound to human TNF-α without cross-reactivity with the homologous murine...

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Main Authors: Song, Moo-Young, Park, Sang-Koo, Kim, Chang-Suk, Yoo, Tae Hyoung, Kim, Bongtae, Kim, Min-Soo, Kim, Yong-Sung, Kwag, Won Jae, Lee, Byung-Kyu, Baek, Kwanghee
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society of Medical Biochemistry and Molecular Biology 2008
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679312/
https://ncbi.nlm.nih.gov/pubmed/18305396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2008.40.1.35
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