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Humanization and Characterization of an Anti-Human TNF-α Murine Monoclonal Antibody
A murine monoclonal antibody, m357, showing the highly neutralizing activities for human tumor necrosis factor (TNF-α) was chosen to be humanized by a variable domain resurfacing approach. The non-conserved surface residues in the framework regions of both the heavy and light chain variable regions...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031550/ https://ncbi.nlm.nih.gov/pubmed/21305012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016373 |
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