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Requirements for Mutant and Wild-Type Prion Protein Misfolding In Vitro
Misfolding of the prion protein (PrP) plays a central role in the pathogenesis of infectious, sporadic, and inherited prion diseases. Here we use a chemically defined prion propagation system to study misfolding of the pathogenic PrP mutant D177N in vitro. This mutation causes PrP to misfold spontan...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4520438/ https://ncbi.nlm.nih.gov/pubmed/25584902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501495j |
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