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Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis

OBJECTIVES: Amyloid deposits are prevalent in osteoarthritis (OA)-affected joints. This study defined the dominant precursor and determined if the deposits affect chondrocyte functions. METHODS: Amyloid deposition in normal and OA human knee cartilage was determined by Congo red staining. Transthyre...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Akasaki, Yukio, Reixach, Natàlia, Matsuzaki, Tokio, Alvarez-Garcia, Oscar, Olmer, Merissa, Iwamoto, Yukihide, Buxbaum, Joel N., Lotz, Martin K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519374/
https://ncbi.nlm.nih.gov/pubmed/25940564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39178
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