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The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling

OBJECTIVE: Persistent fibroblast activation underlies skin fibrosis in systemic sclerosis (SSc), but the transcriptional and epigenetic mechanisms controlling this process are not well understood. In view of the potent influence of acetylation status governing tissue fibrosis, we undertook this stud...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Wei, Jun, Ghosh, Archit K., Chu, Haiyan, Fang, Feng, Hinchcliff, Monique E., Wang, Jiucun, Marangoni, Roberta Goncalves, Varga, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518870/
https://ncbi.nlm.nih.gov/pubmed/25707573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39061
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