The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling

OBJECTIVE: Persistent fibroblast activation underlies skin fibrosis in systemic sclerosis (SSc), but the transcriptional and epigenetic mechanisms controlling this process are not well understood. In view of the potent influence of acetylation status governing tissue fibrosis, we undertook this stud...

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Veröffentlicht in:Arthritis Rheumatol
Hauptverfasser: Wei, Jun, Ghosh, Archit K., Chu, Haiyan, Fang, Feng, Hinchcliff, Monique E., Wang, Jiucun, Marangoni, Roberta Goncalves, Varga, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518870/
https://ncbi.nlm.nih.gov/pubmed/25707573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39061
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