Atomic view of the histidine environment stabilizing higher-pH conformations of pH-dependent proteins

External stimuli are powerful tools that naturally control protein assemblies and functions. For example, during viral entry and exit changes in pH are known to trigger large protein conformational changes. However, the molecular features stabilizing the higher pH structures remain unclear. Here we...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Valéry, Céline, Deville-Foillard, Stéphanie, Lefebvre, Christelle, Taberner, Nuria, Legrand, Pierre, Meneau, Florian, Meriadec, Cristelle, Delvaux, Camille, Bizien, Thomas, Kasotakis, Emmanouil, Lopez-Iglesias, Carmen, Gall, Andrew, Bressanelli, Stéphane, Le Du, Marie-Hélène, Paternostre, Maïté, Artzner, Franck
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518280/
https://ncbi.nlm.nih.gov/pubmed/26190377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8771
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