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Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5
BACKGROUND: The cytoplasmic RIG-like receptors are responsible for the early detection of viruses and other intracellular microbes by activating the innate immune response mediated by type I interferons (IFNs). RIG-I and MDA5 detect virus-specific RNA motifs with short 5′-tri/diphosphorylated, blunt...
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| 發表在: | BMC Biol |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4517655/ https://ncbi.nlm.nih.gov/pubmed/26215161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-015-0166-9 |
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