The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling

BACKGROUND: Characterization of molecular mechanisms underpinning development of pancreatic ductal adenocarcinoma (PDAC) may lead to the identification of novel therapeutic targets and biomarkers. SgK223, also known as Pragmin, is a pseudokinase and scaffolding protein closely related to SgK269/PEAK...

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Publicado en:Mol Cancer
Autores principales: Tactacan, Carole M., Phua, Yu Wei, Liu, Ling, Zhang, Luxi, Humphrey, Emily S., Cowley, Mark, Pinese, Mark, Biankin, Andrew V., Daly, Roger J.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517651/
https://ncbi.nlm.nih.gov/pubmed/26215634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0412-3
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