Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases

SgK269/PEAK1 is a pseudokinase and scaffolding protein that plays a critical role in regulating growth factor receptor signal output and is implicated in the progression of several cancers, including those of the breast, colon, and pancreas. SgK269 is structurally related to SgK223, a human pseudoki...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Liu, Ling, Phua, Yu Wei, Lee, Rachel S., Ma, Xiuquan, Jenkins, Yiping, Novy, Karel, Humphrey, Emily S., Chan, Howard, Shearer, Robert, Ong, Poh Chee, Dai, Weiwen, Saunders, Darren N., Lucet, Isabelle S., Daly, Roger J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076828/
https://ncbi.nlm.nih.gov/pubmed/27531744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748897
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