Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

The mammalian pseudokinase SgK223, and its structurally related homologue SgK269, are oncogenic scaffolds that nucleate the assembly of specific signalling complexes and regulate tyrosine kinase signalling. Both SgK223 and SgK269 form homo- and hetero-oligomers, a mechanism that underpins a diversit...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Patel, Onisha, Griffin, Michael D. W., Panjikar, Santosh, Dai, Weiwen, Ma, Xiuquan, Chan, Howard, Zheng, Celine, Kropp, Ashleigh, Murphy, James M., Daly, Roger J., Lucet, Isabelle S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660093/
https://ncbi.nlm.nih.gov/pubmed/29079850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01279-9
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