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Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association
The mammalian pseudokinase SgK223, and its structurally related homologue SgK269, are oncogenic scaffolds that nucleate the assembly of specific signalling complexes and regulate tyrosine kinase signalling. Both SgK223 and SgK269 form homo- and hetero-oligomers, a mechanism that underpins a diversit...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5660093/ https://ncbi.nlm.nih.gov/pubmed/29079850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01279-9 |
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