Selective suppression of the splicing-mediated microRNA pathway by the terminal uridyltransferase Tailor

Several terminal uridyltransferases (TUTases) are known to modulate small RNA biogenesis and/or function via diverse mechanisms. Here, we demonstrate that Drosophila splicing-derived pre-miRNAs (mirtrons) are efficiently modified by the previously uncharacterized TUTase, Tailor. Tailor is necessary...

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Pubblicato in:Mol Cell
Autori principali: Bortolamiol-Becet, Diane, Hu, Fuqu, Jee, David, Wen, Jiayu, Okamura, Katsutomo, Lin, Ching-Jung, Ameres, Stefan L., Lai, Eric C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517475/
https://ncbi.nlm.nih.gov/pubmed/26145174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.05.034
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