Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene

Pulmonary inflammation can contribute to the development of lung cancer in humans. We investigated whether pulmonary inflammation alters the genotoxicity of polycyclic aromatic hydrocarbons (PAHs) in the lungs of mice and what mechanisms are involved. To model nonallergic acute inflammation, mice we...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Arlt, Volker M., Krais, Annette M., Godschalk, Roger W., Riffo-Vasquez, Yanira, Mrizova, Iveta, Roufosse, Candice A., Corbin, Charmaine, Shi, Quan, Frei, Eva, Stiborova, Marie, van Schooten, Frederik-Jan, Phillips, David H., Spina, Domenico
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Benzo[a]pyrene and Respiratory Tract DNA Damage
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517052/
https://ncbi.nlm.nih.gov/pubmed/25911668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv086
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