The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice

Fanconi anemia is a genetic bone marrow failure syndrome. Current treatment options are suboptimal and do not prevent the eventual onset of aplastic anemia requiring bone marrow transplantation. We previously showed that resveratrol, an antioxidant and an activator of the protein deacetylase Sirt1,...

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Bibliographic Details
Published in:Stem Cell Res
Main Authors: Zhang, Qing-Shuo, Deater, Matthew, Schubert, Kathryn, Marquez-Loza, Laura, Pelz, Carl, Sinclair, David A., Grompe, Markus
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516677/
https://ncbi.nlm.nih.gov/pubmed/26046330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2015.05.007
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