The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice

Fanconi anemia is a genetic bone marrow failure syndrome. Current treatment options are suboptimal and do not prevent the eventual onset of aplastic anemia requiring bone marrow transplantation. We previously showed that resveratrol, an antioxidant and an activator of the protein deacetylase Sirt1,...

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Détails bibliographiques
Publié dans:Stem Cell Res
Auteurs principaux: Zhang, Qing-Shuo, Deater, Matthew, Schubert, Kathryn, Marquez-Loza, Laura, Pelz, Carl, Sinclair, David A., Grompe, Markus
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516677/
https://ncbi.nlm.nih.gov/pubmed/26046330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2015.05.007
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