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Oxymetholone Therapy of Fanconi Anemia Suppresses Osteopontin Transcription and Induces Hematopoietic Stem Cell Cycling

Androgens are widely used for treating Fanconi anemia (FA) and other human bone marrow failure syndromes, but their mode of action remains incompletely understood. Aged Fancd2(−/−) mice were used to assess the therapeutic efficacy of oxymetholone (OXM) and its mechanism of action. Eighteen-month-old...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Stem Cell Reports
मुख्य लेखकों: Zhang, Qing-Shuo, Benedetti, Eric, Deater, Matthew, Schubert, Kathryn, Major, Angela, Pelz, Carl, Impey, Soren, Marquez-Loza, Laura, Rathbun, R. Keaney, Kato, Shigeaki, Bagby, Grover C., Grompe, Markus
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Elsevier 2014
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297866/
https://ncbi.nlm.nih.gov/pubmed/25434823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.10.014
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