Oxymetholone Therapy of Fanconi Anemia Suppresses Osteopontin Transcription and Induces Hematopoietic Stem Cell Cycling

Androgens are widely used for treating Fanconi anemia (FA) and other human bone marrow failure syndromes, but their mode of action remains incompletely understood. Aged Fancd2(−/−) mice were used to assess the therapeutic efficacy of oxymetholone (OXM) and its mechanism of action. Eighteen-month-old...

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Publicado en:Stem Cell Reports
Autores principales: Zhang, Qing-Shuo, Benedetti, Eric, Deater, Matthew, Schubert, Kathryn, Major, Angela, Pelz, Carl, Impey, Soren, Marquez-Loza, Laura, Rathbun, R. Keaney, Kato, Shigeaki, Bagby, Grover C., Grompe, Markus
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297866/
https://ncbi.nlm.nih.gov/pubmed/25434823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.10.014
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