Oxymetholone Therapy of Fanconi Anemia Suppresses Osteopontin Transcription and Induces Hematopoietic Stem Cell Cycling

Androgens are widely used for treating Fanconi anemia (FA) and other human bone marrow failure syndromes, but their mode of action remains incompletely understood. Aged Fancd2(−/−) mice were used to assess the therapeutic efficacy of oxymetholone (OXM) and its mechanism of action. Eighteen-month-old...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Zhang, Qing-Shuo, Benedetti, Eric, Deater, Matthew, Schubert, Kathryn, Major, Angela, Pelz, Carl, Impey, Soren, Marquez-Loza, Laura, Rathbun, R. Keaney, Kato, Shigeaki, Bagby, Grover C., Grompe, Markus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297866/
https://ncbi.nlm.nih.gov/pubmed/25434823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.10.014
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