Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice

Fanconi anemia (FA) is an inherited bone marrow failure disorder associated with a high incidence of leukemia and solid tumors. Bone marrow transplantation is currently the only curative therapy for the hematopoietic complications of this disorder. However, long-term morbidity and mortality remain v...

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Vydáno v:Blood
Hlavní autoři: Zhang, Qing-Shuo, Tang, Weiliang, Deater, Matthew, Phan, Ngoc, Marcogliese, Andrea N., Li, Hui, Al-Dhalimy, Muhsen, Major, Angela, Olson, Susan, Monnat, Raymond J., Grompe, Markus
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2016
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159699/
https://ncbi.nlm.nih.gov/pubmed/27756748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-683490
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