The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice

Fanconi anemia is a genetic bone marrow failure syndrome. Current treatment options are suboptimal and do not prevent the eventual onset of aplastic anemia requiring bone marrow transplantation. We previously showed that resveratrol, an antioxidant and an activator of the protein deacetylase Sirt1,...

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Publicado en:Stem Cell Res
Main Authors: Zhang, Qing-Shuo, Deater, Matthew, Schubert, Kathryn, Marquez-Loza, Laura, Pelz, Carl, Sinclair, David A., Grompe, Markus
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516677/
https://ncbi.nlm.nih.gov/pubmed/26046330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2015.05.007
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