The Xist lncRNA directly interacts with SHARP to silence transcription through HDAC3

Many long non-coding RNAs (lncRNAs) affect gene expression(1), but the mechanisms by which they act are still largely unknown(2). One of the best-studied lncRNAs is Xist, which is required for transcriptional silencing of one X-chromosome during development in female mammals(3,4). Despite extensive...

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Publicat a:Nature
Autors principals: McHugh, Colleen A., Chen, Chun-Kan, Chow, Amy, Surka, Christine F., Tran, Christina, McDonel, Patrick, Pandya-Jones, Amy, Blanco, Mario, Burghard, Christina, Moradian, Annie, Sweredoski, Michael J., Shishkin, Alexander A., Su, Julia, Lander, Eric S., Hess, Sonja, Plath, Kathrin, Guttman, Mitchell
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516396/
https://ncbi.nlm.nih.gov/pubmed/25915022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14443
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