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The Xist lncRNA directly interacts with SHARP to silence transcription through HDAC3
Many long non-coding RNAs (lncRNAs) affect gene expression(1), but the mechanisms by which they act are still largely unknown(2). One of the best-studied lncRNAs is Xist, which is required for transcriptional silencing of one X-chromosome during development in female mammals(3,4). Despite extensive...
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Publicado no: | Nature |
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Main Authors: | , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4516396/ https://ncbi.nlm.nih.gov/pubmed/25915022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14443 |
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