TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma

The ten-eleven-translocation 5-methylcytosine dioxygenase (TET) family of enzymes catalyzes the conversion of 5-methylcytosine (5-mC) to 5-hydroxyme-thylcytosine (5-hmC), a modified cytosine base that facilitates gene expression. Cells respond to hypoxia by inducing a transcriptional program regulat...

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Pubblicato in:Cell Rep
Autori principali: Mariani, Christopher J., Vasanthakumar, Aparna, Madzo, Jozef, Yesilkanal, Ali, Bhagat, Tushar, Yu, Yiting, Bhattacharyya, Sanchari, Wenger, Roland H., Cohn, Susan L., Nanduri, Jayasri, Verma, Amit, Prabhakar, Nanduri R., Godley, Lucy A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516227/
https://ncbi.nlm.nih.gov/pubmed/24835990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.04.040
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