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Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease
The paucity of regulatory T cells (Tregs) limits clinical translation to control aberrant immune reactions including graft-versus-host disease (GVHD). Recent studies showed that the agonistic antibody to DR3 (αDR3) expanded CD4(+)FoxP3(+) Tregs in vivo. We investigated whether treating donor mice wi...
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| Publié dans: | Blood |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4513255/ https://ncbi.nlm.nih.gov/pubmed/26063163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-637587 |
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