Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease

The paucity of regulatory T cells (Tregs) limits clinical translation to control aberrant immune reactions including graft-versus-host disease (GVHD). Recent studies showed that the agonistic antibody to DR3 (αDR3) expanded CD4(+)FoxP3(+) Tregs in vivo. We investigated whether treating donor mice wi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Kim, Byung-Su, Nishikii, Hidekazu, Baker, Jeanette, Pierini, Antonio, Schneidawind, Dominik, Pan, Yuqiong, Beilhack, Andreas, Park, Chung-Gyu, Negrin, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513255/
https://ncbi.nlm.nih.gov/pubmed/26063163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-637587
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