The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing

We report the production and metabolic phenotype of a mouse line in which the Fmo5 gene is disrupted. In comparison with wild-type (WT) mice, Fmo5(−/−) mice exhibit a lean phenotype, which is age-related, becoming apparent after 20 weeks of age. Despite greater food intake, Fmo5(−/−) mice weigh less...

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Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R., Shephard, Elizabeth A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509511/
https://ncbi.nlm.nih.gov/pubmed/26049045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.05.013
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