The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing

We report the production and metabolic phenotype of a mouse line in which the Fmo5 gene is disrupted. In comparison with wild-type (WT) mice, Fmo5(−/−) mice exhibit a lean phenotype, which is age-related, becoming apparent after 20 weeks of age. Despite greater food intake, Fmo5(−/−) mice weigh less...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Biochem Pharmacol
Autori principali: Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R., Shephard, Elizabeth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Science 2015
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509511/
https://ncbi.nlm.nih.gov/pubmed/26049045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.05.013
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi