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5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing Conditions in Nucleoside and DNA Contexts
[Image: see text] Exogenously and endogenously produced reactive oxygen species attack the base and sugar moieties of DNA showing a preference for reaction at 2′-deoxyguanosine (dG) sites. In the present work, dG was oxidized by HO(•) via the Fe(II)-Fenton reaction or by X-ray radiolysis of water. T...
Salvato in:
| Pubblicato in: | J Org Chem |
|---|---|
| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2015
|
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4509422/ https://ncbi.nlm.nih.gov/pubmed/26092110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.5b00689 |
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