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The guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair
Guanine (G) is a target for oxidation by reactive oxygen species in DNA, RNA and the nucleotide pool. Damage to DNA yields products with alternative properties toward DNA processing enzymes compared to the parent nucleotide. A new lesion, 5-carboxamido-5-formamido-2-iminohydantoin (2Ih) bearing a st...
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| Publicado no: | Chem Res Toxicol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4807729/ https://ncbi.nlm.nih.gov/pubmed/26313343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00302 |
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