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The guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair

Guanine (G) is a target for oxidation by reactive oxygen species in DNA, RNA and the nucleotide pool. Damage to DNA yields products with alternative properties toward DNA processing enzymes compared to the parent nucleotide. A new lesion, 5-carboxamido-5-formamido-2-iminohydantoin (2Ih) bearing a st...

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Bibliografiske detaljer
Udgivet i:Chem Res Toxicol
Main Authors: Alshykhly, Omar R., Fleming, Aaron M., Burrows, Cynthia J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807729/
https://ncbi.nlm.nih.gov/pubmed/26313343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00302
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