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Leukemia cells are sensitized to temozolomide, carmustine and melphalan by the inhibition of O(6)-methylguanine-DNA methyltransferase
The cytotoxicity of the monofunctional alkylator, temozolomide (TMZ), is known to be mediated by mismatch repair (MMR) triggered by O(6)-alkylguanine. By contrast, the cytotoxicity of bifunctional alkylators, including carmustine (BCNU) and melphalan (MEL), depends on interstrand crosslinks formed t...
Gorde:
| Argitaratua izan da: | Oncol Lett |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
D.A. Spandidos
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4509097/ https://ncbi.nlm.nih.gov/pubmed/26622581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2015.3307 |
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