Leukemia cells are sensitized to temozolomide, carmustine and melphalan by the inhibition of O(6)-methylguanine-DNA methyltransferase

The cytotoxicity of the monofunctional alkylator, temozolomide (TMZ), is known to be mediated by mismatch repair (MMR) triggered by O(6)-alkylguanine. By contrast, the cytotoxicity of bifunctional alkylators, including carmustine (BCNU) and melphalan (MEL), depends on interstrand crosslinks formed t...

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Veröffentlicht in:Oncol Lett
Hauptverfasser: ARAI, HAJIME, YAMAUCHI, TAKAHIRO, UZUI, KANAKO, UEDA, TAKANORI
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509097/
https://ncbi.nlm.nih.gov/pubmed/26622581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2015.3307
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