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A β-Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase
The potent immucillin purine nucleoside phosphorylase (PNP) inhibitors F-DADMe-ImmH [(3S,4S)−3], and [(3R,4R)−3] are synthesized in seven steps. Cycloaddition to a fluoroalkene and an enzymic resolution are the key features of the construction of the fluoropyrrolidines 11, from which the immucillins...
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| 發表在: | J Med Chem |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4508846/ https://ncbi.nlm.nih.gov/pubmed/18800772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800792b |
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