Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.

During T-cell development CD3-CD4-CD8- (double-negative) thymocytes proliferative and produce an enormous number of CD3loCD4+CD8+ (double-positive) thymocytes which are destined to die intrathymically unless rescued by positive selection. Those which survive become mature CD3hiCD4/8+ (single-positiv...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Gratiot-Deans, J, Merino, R, Nuñez, G, Turka, L A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45086/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7938012/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.22.10685
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