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Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.

During T-cell development CD3-CD4-CD8- (double-negative) thymocytes proliferative and produce an enormous number of CD3loCD4+CD8+ (double-positive) thymocytes which are destined to die intrathymically unless rescued by positive selection. Those which survive become mature CD3hiCD4/8+ (single-positiv...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Gratiot-Deans, J, Merino, R, Nuñez, G, Turka, L A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45086/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7938012/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.22.10685
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