Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.
During T-cell development CD3-CD4-CD8- (double-negative) thymocytes proliferative and produce an enormous number of CD3loCD4+CD8+ (double-positive) thymocytes which are destined to die intrathymically unless rescued by positive selection. Those which survive become mature CD3hiCD4/8+ (single-positiv...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1994
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45086/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7938012/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.22.10685 |
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