Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.

During T-cell development CD3-CD4-CD8- (double-negative) thymocytes proliferative and produce an enormous number of CD3loCD4+CD8+ (double-positive) thymocytes which are destined to die intrathymically unless rescued by positive selection. Those which survive become mature CD3hiCD4/8+ (single-positiv...

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Bibliographic Details
Main Authors: Gratiot-Deans, J, Merino, R, Nuñez, G, Turka, L A
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC45086/
https://ncbi.nlm.nih.gov/pubmed/7938012
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