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Stability-enhanced Hot-melt Extruded Amorphous Solid Dispersions via Combinations of Soluplus® and HPMCAS-HF

The aim of this study was to evaluate a novel combination of Soluplus® and hypromellose acetate succinate (HPMCAS-HF) polymers for solubility enhancement as well as enhanced physicochemical stability of the produced amorphous solid dispersions. This was accomplished by converting the poorly water-so...

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Detalhes bibliográficos
Publicado no:AAPS PharmSciTech
Main Authors: Alshahrani, Saad M., Lu, Wenli, Park, Jun-Bom, Morott, Joseph T., Alsulays, Bader B., Majumdar, Soumyajit, Langley, Nigel, Kolter, Karl, Gryczke, Andreas, Repka, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508305/
https://ncbi.nlm.nih.gov/pubmed/25567525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-014-0269-6
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