Hot melt extrusion as an approach to improve solubility, permeability and oral absorption of a psychoactive natural product, piperine

OBJECTIVE: The aims of the current research project were to investigate the efficiency of various polymers to enhance the solubility and increase the systemic absorption of piperine using hot melt extrusion technology. METHODS: Piperine 10–40% w/w and Eudragit® EPO/Kollidon® VA 64 or Soluplus® were...

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Publicat a:J Pharm Pharmacol
Autors principals: Ashour, Eman A, Majumdar, Soumyajit, Alsheteli, Abdulla, Alshehri, Sultan, Alsulays, Bader, Feng, Xin, Gryczke, Andreas, Kolter, Karl, Langley, Nigel, Repka, Michael A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931965/
https://ncbi.nlm.nih.gov/pubmed/27283755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jphp.12579
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