Hot melt extrusion as an approach to improve solubility, permeability and oral absorption of a psychoactive natural product, piperine

OBJECTIVE: The aims of the current research project were to investigate the efficiency of various polymers to enhance the solubility and increase the systemic absorption of piperine using hot melt extrusion technology. METHODS: Piperine 10–40% w/w and Eudragit® EPO/Kollidon® VA 64 or Soluplus® were...

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Bibliografische gegevens
Gepubliceerd in:J Pharm Pharmacol
Hoofdauteurs: Ashour, Eman A, Majumdar, Soumyajit, Alsheteli, Abdulla, Alshehri, Sultan, Alsulays, Bader, Feng, Xin, Gryczke, Andreas, Kolter, Karl, Langley, Nigel, Repka, Michael A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2016
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931965/
https://ncbi.nlm.nih.gov/pubmed/27283755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jphp.12579
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