Optimization of hot melt extrusion parameters for sphericity and hardness of polymeric face-cut pellets

The aim of this study was to formulate face-cut, melt extruded pellets and to optimize hot melt process parameters to obtain maximized sphericity and hardness by utilizing Soluplus(®) as a polymeric carrier and carbamazepine (CBZ) as a model drug. Thermal gravimetric analysis (TGA) was used to detec...

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Detalhes bibliográficos
Publicado no:Drug Dev Ind Pharm
Main Authors: Alshetaili, Abdullah S., Almutairy, Bjad K., Alshahrani, Saad M., Ashour, Eman A., Tiwari, Roshan V., Alshehri, Sultan M., Feng, Xin, Alsulays, Bader B., Majumdar, Soumyajit, Langley, Nigel, Kolter, Karl, Gryczke, Andreas, Martin, Scott T., Repka, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041532/
https://ncbi.nlm.nih.gov/pubmed/27080252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/03639045.2016.1178769
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