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Solid-state Characterization of Felodipine-Soluplus(®) Amorphous Solid Dispersions

The aim of the current study is to develop amorphous solid dispersion via hot melt extrusion technology to improve the solubility of a water-insoluble compound, felodipine. The solubility was dramatically increased by preparation of amorphous solid dispersions via hot-melt extrusion with an amphiphi...

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Detalhes bibliográficos
Publicado no:Drug Dev Ind Pharm
Main Authors: Lu, Jiannan, Cuellar, Kristina, Hammer, Nathan I., Jo, Seongbong, Gryczke, Andreas, Kolter, Karl, Langley, Nigel, Repka, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933522/
https://ncbi.nlm.nih.gov/pubmed/26530290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03639045.2015.1104347
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