Liver-directed gene therapy of chronic hepadnavirus infection using interferon alpha tethered to apolipoprotein A-I

BACKGROUND & AIMS: Current HBV management is challenging as treatment with nucleos(t)ide analogs needs to be maintained indefinitely and because IFNα therapy is associated with considerable toxicity. Previously we showed that linking IFNα to apolipoprotein A-I generates a molecule (IA) with dist...

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發表在:J Hepatol
Main Authors: Berraondo, Pedro, Di Scala, Marianna, Korolowicz, Kyle, Thampi, Linta M., Otano, Itziar, Suarez, Lester, Fioravanti, Jessica, Aranda, Fernando, Ardaiz, Nuria, Yang, Junming, Kallakury, Bhaskar V., Tucker, Robin D., Vasquez, Marcos, Menne, Stephan, Prieto, Jesús, González-Aseguinolaza, Gloria
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508219/
https://ncbi.nlm.nih.gov/pubmed/25772035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.02.048
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