Liver-directed gene therapy of chronic hepadnavirus infection using interferon alpha tethered to apolipoprotein A-I

BACKGROUND & AIMS: Current HBV management is challenging as treatment with nucleos(t)ide analogs needs to be maintained indefinitely and because IFNα therapy is associated with considerable toxicity. Previously we showed that linking IFNα to apolipoprotein A-I generates a molecule (IA) with dist...

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Publicado no:J Hepatol
Main Authors: Berraondo, Pedro, Di Scala, Marianna, Korolowicz, Kyle, Thampi, Linta M., Otano, Itziar, Suarez, Lester, Fioravanti, Jessica, Aranda, Fernando, Ardaiz, Nuria, Yang, Junming, Kallakury, Bhaskar V., Tucker, Robin D., Vasquez, Marcos, Menne, Stephan, Prieto, Jesús, González-Aseguinolaza, Gloria
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508219/
https://ncbi.nlm.nih.gov/pubmed/25772035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.02.048
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