Liver-directed gene therapy of chronic hepadnavirus infection using interferon alpha tethered to apolipoprotein A-I

BACKGROUND & AIMS: Current HBV management is challenging as treatment with nucleos(t)ide analogs needs to be maintained indefinitely and because IFNα therapy is associated with considerable toxicity. Previously we showed that linking IFNα to apolipoprotein A-I generates a molecule (IA) with dist...

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Publicat a:J Hepatol
Autors principals: Berraondo, Pedro, Di Scala, Marianna, Korolowicz, Kyle, Thampi, Linta M., Otano, Itziar, Suarez, Lester, Fioravanti, Jessica, Aranda, Fernando, Ardaiz, Nuria, Yang, Junming, Kallakury, Bhaskar V., Tucker, Robin D., Vasquez, Marcos, Menne, Stephan, Prieto, Jesús, González-Aseguinolaza, Gloria
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508219/
https://ncbi.nlm.nih.gov/pubmed/25772035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.02.048
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