Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

Nucleoside analog reverse transcriptase inhibitors (NRTIs) are the essential components of highly active antiretroviral (HAART) therapy targeting HIV reverse transcriptase (RT). NRTI triphosphates (NRTI-TP), the biologically active forms, act as chain terminators of viral DNA synthesis. Unfortunatel...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Sohl, Christal D., Szymanski, Michal R., Mislak, Andrea C., Shumate, Christie K., Amiralaei, Sheida, Schinazi, Raymond F., Anderson, Karen S., Yin, Y. Whitney
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507203/
https://ncbi.nlm.nih.gov/pubmed/26124101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421733112
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