The DNA Polymerase Gamma R953C Mutant Is Associated with Antiretroviral Therapy-Induced Mitochondrial Toxicity

We found a heterozygous C2857T mutation (R953C) in polymerase gamma (Pol-γ) in an HIV-infected patient with mitochondrial toxicity. The R953C Pol-γ mutant binding affinity for dCTP is 8-fold less than that of the wild type. The R953C mutant shows a 4-fold decrease in discrimination of analog nucleot...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Li, Min, Mislak, Andrea C., Foli, Yram, Agbosu, Esinam, Bose, Vivek, Bhandari, Shreya, Szymanski, Michal R., Shumate, Christie K., Yin, Y. Whitney, Anderson, Karen S., Paintsil, Elijah
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2016
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997837/
https://ncbi.nlm.nih.gov/pubmed/27381400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00976-16
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