Antiretroviral Therapy-Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase-γ Inhibition

We hypothesized that competition between NRTI-triphosphate and endogenous deoxyribonucleoside triphosphate (dNTP) may lead to depletion of dNTP pools and mitochondrial dysfunction independent of Pol-γ inhibition. We collected peripheral blood mononuclear cells from 75 adults (25 cases: HIV-infected...

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Main Authors: Selvaraj, Shanmugapriya, Ghebremichael, Musie, Li, Min, Foli, Yram, Langs-Barlow, Allison, Ogbuagu, Arit, Barakat, Lydia, Tubridy, Elizabeth, Edifor, Regina, Lam, Wing, Cheng, Yung-Chi, Paintsil, Elijah
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065195/
https://ncbi.nlm.nih.gov/pubmed/24637942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2014.64
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