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Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ
Nucleoside analog reverse transcriptase inhibitors (NRTIs) are the essential components of highly active antiretroviral (HAART) therapy targeting HIV reverse transcriptase (RT). NRTI triphosphates (NRTI-TP), the biologically active forms, act as chain terminators of viral DNA synthesis. Unfortunatel...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4507203/ https://ncbi.nlm.nih.gov/pubmed/26124101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421733112 |
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