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Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase
The human DNA polymerase gamma (Pol γ) is responsible for DNA replication in mitochondria. Pol γ is particularly susceptible to inhibition by dideoxynucleoside-based inhibitors designed to fight viral infection. Here, we report crystal structures of the replicating Pol γ–DNA complex bound to either...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4547898/ https://ncbi.nlm.nih.gov/pubmed/26056153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591520 |
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