Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys

BACKGROUND AND PURPOSE: Using an innovative chemical approach, peptide welding technology (PWT), a tetrabranched derivative of nociceptin/orphanin FQ (N/OFQ) has been generated and pharmacologically characterized. Both in vitro and in vivo PWT2-N/OFQ displayed the same pharmacological profile to the...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Rizzi, A, Sukhtankar, D D, Ding, H, Hayashida, K, Ruzza, C, Guerrini, R, Calò, G, Ko, M C
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2015
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507167/
https://ncbi.nlm.nih.gov/pubmed/25828800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13150
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