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Antinociceptive Effects of Nociceptin/Orphanin FQ Administered Intrathecally in Monkeys
Nociceptin/orphanin FQ (N/OFQ) is the endogenous peptide for the NOP receptors. Depending on the doses, intrathecal administration of N/OFQ has dual actions (ie, hyperalgesia and antinociception) in rodents. However, the pharmacological profile of intrathecal N/OFQ is not fully known in primates. Th...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2797530/ https://ncbi.nlm.nih.gov/pubmed/19231294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2008.11.006 |
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