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Antinociceptive Effects of Nociceptin/Orphanin FQ Administered Intrathecally in Monkeys

Nociceptin/orphanin FQ (N/OFQ) is the endogenous peptide for the NOP receptors. Depending on the doses, intrathecal administration of N/OFQ has dual actions (ie, hyperalgesia and antinociception) in rodents. However, the pharmacological profile of intrathecal N/OFQ is not fully known in primates. Th...

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Hlavní autoři: Ko, Mei-Chuan, Naughton, Norah N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797530/
https://ncbi.nlm.nih.gov/pubmed/19231294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2008.11.006
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