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Gemin5 Binds to the Survival Motor Neuron mRNA to Regulate SMN Expression
Reduced expression of SMN causes spinal muscular atrophy, a severe neurodegenerative disease. Despite the importance of maintaining SMN levels, relatively little is known about the mechanisms by which SMN levels are regulated. We show here that Gemin5, the snRNA-binding protein of the SMN complex, b...
Tallennettuna:
| Julkaisussa: | J Biol Chem |
|---|---|
| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4505476/ https://ncbi.nlm.nih.gov/pubmed/25911097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.646257 |
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