Dynamics of survival of motor neuron (SMN) protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons

Spinal muscular atrophy (SMA) is a lethal neurodegenerative disease specifically affecting spinal motor neurons. SMA is caused by the homozygous deletion or mutation of the survival of motor neuron 1 (SMN1) gene. The SMN protein plays an essential role in the assembly of spliceosomal ribonucleoprote...

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Detalhes bibliográficos
Main Authors: Fallini, Claudia, Rouanet, Jeremy P., Donlin-Asp, Paul G., Guo, Peng, Zhang, Honglai, Singer, Robert H., Rossoll, Wilfried, Bassell, Gary J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906212/
https://ncbi.nlm.nih.gov/pubmed/23897586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dneu.22111
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