Leptin Elongates Hypothalamic Neuronal Cilia via Transcriptional Regulation and Actin Destabilization

Terminally differentiated neurons have a single, primary cilium. The primary cilia of hypothalamic neurons play a critical role in sensing metabolic signals. We recently showed that mice with leptin deficiency or resistance have shorter cilia in the hypothalamic neurons, and leptin treatment elongat...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Kang, Gil Myoung, Han, Yu Mi, Ko, Hyuk Whan, Kim, Joon, Oh, Byung Chul, Kwon, Ijoo, Kim, Min-Seon
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505059/
https://ncbi.nlm.nih.gov/pubmed/26041775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.639468
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